Pharmaceutics
2020, 12, 735
2 of 30
treatments, such as debridement. This review focuses on the wound healing process, providing a deep
description and analysis of wound healing mechanisms.
Wound medications evolving from simple “coating” devices to advanced medications, as well as
their advantages and limitations in the skin regeneration process, will be investigated. In particular,
this review is focused on the progress in wound medication and its development in recent years.
The main complications related to the healing process and the clinical management of chronic wounds
are described in the review. Moreover, advanced treatment strategies for skin regeneration and
experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging
skin regeneration techniques involving sca
ffolds activated with growth factors, bioactive molecules
and genetically modified cells are exploited to overcome wound healing technology limitations and to
implement personalized therapy design.
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