Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
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| 8. Conclusions
Despite the enormous advances in wound healing therapies in recent years, the most di fficult challenge in skin regeneration is to obtain a tissue containing microvessels, hair follicles and sweat glands. Three-dimensional bioprinting has an important potential for wound healing, but the challenge remains in designing a precise and complex hierarchy in new tissues, allowing di fferent types of cells to coexist and to have unique 3D models. Therefore, one of the key areas for 3D bioprinting improvement is to provide bioinks suitable for di fferent types of cells. Biodegradable and biocompatible polymers of natural origin are the preferred candidates and combinations. Technological limitations due to cell damage caused by the 3D bioprinting process and due to the rheological properties required to obtain a 3D bioprinted construct can be overcome by new 3D bioprinter designs. A great opportunity in the near future lies in combining 3D bioprinting with electrospinning. This will enable the possibility of manufacturing sca ffolds with improved mechanical resistance properties and cell engineering. Given the extent and increasing prevalence of various types of skin injuries, skin regeneration is a challenge that requires close collaboration between researchers in many disciplines. Many innovative strategies have been implemented to address wound healing due to the easy accessibility of target tissue; the design of innovative and more functional strategies to translate technologies into clinical therapies represents a great challenge for biomaterial researchers and biomedical engineers. Pharmaceutics 2020, 12, 735 25 of 30 Advances in research will lead to improved wound healing treatments in terms of ameliorating skin reconstruction and scar formation. The impact on real-world outcomes will be an improvement of life-threatening situations, with the aim being to restore to normal life conditions, even for patients su ffering from severe wounds of different origins. Baixar 2.23 Mb. Compartilhe com seus amigos:
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