8. Conclusions Despite the enormous advances in wound healing therapies in recent years, the most di
challenge in skin regeneration is to obtain a tissue containing microvessels, hair follicles and sweat
glands. Three-dimensional bioprinting has an important potential for wound healing, but the challenge
remains in designing a precise and complex hierarchy in new tissues, allowing di
fferent types of cells to
coexist and to have unique 3D models. Therefore, one of the key areas for 3D bioprinting improvement
is to provide bioinks suitable for di
fferent types of cells. Biodegradable and biocompatible polymers of
natural origin are the preferred candidates and combinations. Technological limitations due to cell
damage caused by the 3D bioprinting process and due to the rheological properties required to obtain
a 3D bioprinted construct can be overcome by new 3D bioprinter designs. A great opportunity in the
near future lies in combining 3D bioprinting with electrospinning. This will enable the possibility of
ffolds with improved mechanical resistance properties and cell engineering.
Given the extent and increasing prevalence of various types of skin injuries, skin regeneration is a
challenge that requires close collaboration between researchers in many disciplines. Many innovative
strategies have been implemented to address wound healing due to the easy accessibility of target
tissue; the design of innovative and more functional strategies to translate technologies into clinical
therapies represents a great challenge for biomaterial researchers and biomedical engineers.
Pharmaceutics 2020, 12, 735
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Advances in research will lead to improved wound healing treatments in terms of ameliorating
skin reconstruction and scar formation. The impact on real-world outcomes will be an improvement of
life-threatening situations, with the aim being to restore to normal life conditions, even for patients
ffering from severe wounds of different origins.