Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration Erika Maria Tottoli 1 , Rossella Dorati 1, * , Ida Genta 1 , Enrica Chiesa 1 , Silvia Pisani 2 and Bice Conti 1 1
Department of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy;
firstname.lastname@example.org (E.M.T.); email@example.com (I.G.); firstname.lastname@example.org (E.C.);
Immunology and Transplantation Laboratory, Pediatric Hematology Oncology Unit, Department of
Maternal and Children’s Health, Fondazione IRCCS Policlinico S. Matteo, 27100 Pavia, Italy;
* Correspondence: email@example.com; Tel.:
Received: 22 June 2020; Accepted: 31 July 2020; Published: 5 August 2020
Abstract: Skin wound healing shows an extraordinary cellular function mechanism, unique in
nature and involving the interaction of several cells, growth factors and cytokines. Physiological
wound healing restores tissue integrity, but in many cases the process is limited to wound repair.
Ongoing studies aim to obtain more e
ffective wound therapies with the intention of reducing inpatient
costs, providing long-term relief and e
ffective scar healing. The main goal of this comprehensive
review is to focus on the progress in wound medication and how it has evolved over the years.
The main complications related to the healing process and the clinical management of chronic wounds
are described in the review. Moreover, advanced treatment strategies for skin regeneration and
experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging
skin regeneration techniques involving sca
ffolds activated with growth factors, bioactive molecules
and genetically modified cells are exploited to overcome wound healing technology limitations and
to implement personalized therapy design.