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How to cite this article:

Nascimento CM, Machado AM, Guerra JC, Zlotnik E, Campêlo DH, Kauffman P, et al. Consensus on the investigation of thrombophilia in women and clinical management. einstein (São Paulo). 2019;17(X):eAE4510.

Corresponding author:

Claudia Mac Donald Bley Nascimento

Avenida Albert Einstein, 627/701 − Morumbi

Zip code: 05651-901 − São Paulo, SP, Brazil

Received on:

May 4, 2018

Accepted on:

Dec 26, 2018

Conflict of interest:



Objective: To standardize the investigation and clinical management of women with laboratory and/or clinical abnormalities suggestive of thrombophilia, in order to optimize antithrombotic approach and indication of laboratory tests. Methods: A discussion was carried out among 107 physicians (gynecologists/obstetricians, hematologists and vascular surgeons) present at a forum held at the Hospital Israelita Albert Einstein, in São Paulo (SP), Brazil. As a minimum criterion, 80% agreement was established in the voting to each recommendation of conduct in the final document. The cases in which there was agreement below 80% were discussed again, reaching a consensual agreement of conduct for the document writing. Results: We reached a consensus of guidelines developed in an interdisciplinary way for investigation and prevention of thromboembolism in women. Conclusion: The standardization of an institutional consensus of suggestions of clinical approach contributes to a better management of the group to be evaluated and minimizes risks of intercurrent events. This was the first national consensus on the investigation of thrombophilia in women.

Keywords: Thrombophilia; Antiphospholipid syndrome; Venous thromboembolism; Pregnancy; Abortion, habitual; Pregnancy complications; Contraception; Venous thrombosis

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