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Women with antiphospholipid syndrome should use antithrombotic prophylaxis both during pregnancy and puerperium, combined with a low dose of acetylsalicylic acid (75-100mg/day): 98% agreement

The investigation of antiphospholipid syndrome should be done in women with a history of arterial/VTE and obstetric morbidity (more than three consecutive early pregnancy losses, fetal death within or beyond 10 weeks of pregnancy and severe pre-eclampsia or placental insufficiency that need to deliver before 34 weeks of gestation). The laboratory criteria include persistent positivity for at least one test among lupus anticoagulant, anticardiolipin, and antibodies anti-beta-2-glycoprotein I, in which the laboratory tests should be performed with 12-week intervals. The clinical management of the pregnant patients with antiphospholipid syndrome aims to prevent obstetric complications and maternal thrombotic events.(28) Combined therapy of a low dose of aspirin and heparin is considered the conventional treatment for patients with an established diagnosis of obstetric antiphospholipid syndrome, resulting in more than 70% of successful pregnancies.

On the other hand, the risk of VTE in pregnant women with no history of thrombosis and with positive antibody antiphospholipid is similar to the risk of the pregnant women with no antibodies, and there are no reasons for antithrombotic prophylaxis in this group of women.(29)

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