dosage to be administered, Medline was used for searching the most relevant prospective research papers on this subject in order to
evaluate current evidence about the use of aspirin in this context. Relevant citations were extracted from Embase, PubMed and the
Cochrane Central Register of Controlled Trials. We divided the studies in two groups; one with aspirine administration before 16 weeks
and the other having a larger use, between the first and the third trimester.