to studies and controversies for the last 30 years. The first research results concerning the role of placenta in preeclampsia have been
published by the end of seventies and they showed an increase in the platelet activity and a prostaglandin synthesis disturbance, as
a consequence of a deficient placentation. In the last twenty years of the XX century important studies were published on the aspirin
prophylactic role in preeclampsia risk reduction.